Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children's Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute lymphoblastic leukemia (ALL).
The study also showed that Hispanic patients were more likely than patients of European or African ancestry to inherit high-risk versions of two of these genes. This discovery points to at least one reason for that difference.
Inherited Genetic Variations Have Major Impact on Childhood Leukemia Risk
Art and Science of Laboratory Medicine
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